Bano S, Ghafoor S, Naseem N.
Cytological Changes IN Rat`s Sublingual Salivary Gland Developing Produced By Thyroid Hormone Administration During Postnatal Peroid.
Biomedica Jan ;33(3):206-10.

Background and Objective: Thyroid plays hormone essential role in normal growth, cytodifferentiation and proliferation and can have an influence on normal development of the salivary glands. Sublingual salivary gland is the smallest of the three major salivary glands that lies in close proximity to the submandibular gland. It has been shown that administration of T3 which is the metabolically active form of thyroid hormone can affect growth factors produced by the salivary glands, however it needs to be investigated if the exogenous administration of T3 can also cause any morphological or cytological changes in the sublingual tissue. Methods: After obtaining ethical approval, twenty four healthy Wister rats taken at age week three and week seven were divided into two control (A1, A2) and two experimental groups (B1, B2) having six rats in each group respectively. The control and experimental animals were subcutaneously injected either normal saline or T3 at a dose of 0.5 mg/kg body weight, every alternate day for fourteen days. Animals were scarified on the fifteenth day and sublingual salivary gland was processed for macroscopic and histological analysis. Results: No significant difference in gross appearance of sublingual salivary glands of control and experimental groups was found. The histological examination of all the four groups also revealed normal parenchymal and stromal components. Conclusion: Thyroid hormone administration did not affect the early postnatal development of the sublingual salivary gland in low dosage.

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