Ammar T, Aziz M.
Demographic Features of Chronic Myeloproliferative Neoplasms Presenting at Shaikh Zayed Medical Complex, Lahore.
Biomedica Jan ;33(3):169-73.

Background and Objectives: The term myeloproliferative neoplasms (MPN) was first introduced by William Dameshek in 1951 to emphasize the clinicopathological similarities between chronic myeloid leukemia (CML), essential thrombocythemia (ET), polycythemia vera (PV), and with myeloid metaplasia (MMM) ( Also known as, chronic idiopathic myelofibrosis or primary myelofibrosis) Accordingly, these 4 disorders are currently referred to as ?classic? MPN. However, several CMPN-like clinicopathological entities have since been described and, at present the World Health Organization (WHO) system for classification of myeloid neoplasms organize classic MPN as a completely separate category. The objective of the study was to evaluate the demographic features of chronic myeloproliferative neoplasms (CMPN). Methods: Cross-sectional descriptive study was carried out at Haematology Department, Shaikh Zayed Hospital, Lahore from 4th April 2007 to 4th April 2013. This study comprised of two hundred (200) patients. Patients aged 16 years and above, both genders and diagnosed cases of CMPD were included. Standard procedures were followed for all laboratory tests. Results: In this study 200 patients of CMPN were diagnosed. CML was found to be the commonest and ET was least common. In CML peak incidence was in 4th decade with male preponderance and mean age was 40 years. In IMF mean age was 55 years and peak incidence was in 6th decade while female preponderance was seen. In PRV mean age was 64 years and female preponderance was noted with peak incidence in 7 th decade. In cases of ET mean age was 67 yrs, all patients were male and peak incidence was in 7 th decade. Conclusion: In this study among CMPN Chronic Myeloid Leukemia is commonest of all and Essential Thrombocythemia was found to be least common. Their demographic features were found to be close to international studies. The only difference was female preponderance in IMF in our study while other studies have shown male preponderance.

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