Ahsan Ali Mirza, Syed Amjad Zaidi, Kashif Jamil, Ayesha Saeed, Mohammad Asif, Iram Najeeb.
Metronidazole in Acute Non-perforated Appendicitis.
J Surg Pak Jan ;22(2):39-42.

Objective: To compare the infective complication rate after open appendicectomy in patients with nonperforated appendicitis receiving cefazolin with metronizadole and cefazolin alone. Study design: Randomised controlled trial. Place & Duration of study: PAEC General Hospital Islamabad, from March 2015 to June 2016. Methodology: Patients with acute non-perforated appendicitis were divided into two groups. Group A patients received cefazolin with metronizadole and Group B received only cefazolin. A total of three doses were given, one preoperatively and two postoperatively in each group. Patients in both groups were followed up for 30 days postoperatively for any surgical site infections (SSI). Results: A total of 242 patients were operated of whom 11 were excluded as they did not come for follow-up. There were 111 patients in group A and 120 in group B. Infection rate in group A patients was 7.21 % and in group B, 8.33%. There was no significant difference of wound infection in both the groups (p=0.427). Conclusion: Addition of metronizadole in patients with non-perforated acute appendicitis did not reduce the rate of surgical site infection.

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