Humaira Imtiaz, Wajid Akbar, Usman Ali.
Serum Ferritin; Comparison of Bone age of Thalasemic patients 9 - 15 Years.
Professional Med J Jan ;25(3):454-60.

Objectives: The aims is to determine whether there is any difference between the bone age of thalassemic children with chronological age and serum ferritin and its correlation with normal children of the same age. Study design: This was cross sectional analytical study. Place & Duration: The study was conducted as age sex matched normal control, from Fatimid and Khyber Teaching Hospital Peshawar during August 2014 to January 2015. Material & Methods: A total 156 samples were selected conveniently to make comparison of bone age between thalassemic children (age 9-15years) and control. A structure data collection check list was used to collect data X-ray findings (bone age) and Ferritin level. Data were analyzed using SPSS version 20 and MS Excel. The frequency, proportion, percentages, ratio, means and SD were calculated. Student?s t- test was applied to compare the means of biochemical measures between the two groups, P value ? 0.05. Results: The results indicate total 156 children were included with mean age 11.9 ± 2.2, {97(62.2%) were being males and 59 (37.8%) were being females}. Out of thalassemic (n= 76) majority 49 (62.8%) were male as compare to female 29(37.2%). The bone age was significantly different from control (p = 0001). Similarly the mean ferritin concentrations were also different (P = 0001). Conclusion: Serum ferritin level could be one of the indictors for osteoporosis and thus may play an imperative role in the management of thalassemia patients by early diagnosis and treatment.

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