Muhammad Saleem Shaikh, Muharram Ali, Muhammad Ali Naper.
Colorectal Cancer; Pattern and Distribution of Colorectal Cancer. a Retrospective Hospital Based study at CMCH & LINAR, Larkana.
Professional Med J Jan ;25(5):696-702.

Objectives: To determine the changing clinicopathological pattern and distribution of colorectal cancer in our setup, highlighting future planning and designing for its prevention. Study Design: A retrospective study. Place and Duration: Department of Surgery, Chandka Medical College and LINAR, Larkana from January 2012 to December 2016. Methodology: All the diagnosed cases of colorectal cancer were included in our study. The records analyzed for age, gender, clinical presentation, socioeconomic status, risk factors, histopathological variable types, site of distribution, tumor grading & staging based on TNM. The method of treatment & surgical procedures performed, were also recorded. Statistics data was entered and analyzed by SPSS version 17. Results: 363 diagnosed cases of colorectal cancer were registered from January, 2012 to December, 2016. 211 (58. %) were male and 147 (40.9%) female, with ratio of 1.3:1. Age ranged between 17 to 88 years with mean age of 56 + 12. 217 patients were > 50 years, while 146 < 50 years. The predominant subsite distribution was found in rectum & recto sigmoid junction in 205 cases (56.49%). Majority of cases belong to low socioeconomic class with Duke?s B and C stages (45.73%. and 39.11%). The mortality rate was observed in 12.9%, however 30% of patients were not returned for follow-up. Conclusion: Colorectal cancer is shown rising higher up and vated cancer was found increasing in incidence among young population < 50 years. There is a need of early detection, to reduce the number of CRC in future.

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