Shakila Yasmin, Rukhsana Aziz, Muhammad Hassan, Mehak Fatima.
Termination of Pregnancy; Therapeutic Termination of Pregnancy in Second Trimester.
Professional Med J Jan ;25(6):952-8.

Objectives: To compare efficacy of extra-amniotic Foley?s catheter balloon alone versus combined use of Foley?s catheter balloon and extra-amniotic instillation of prostaglandin F2-alpha in therapeutic termination of second trimester pregnancy. Study Design: Randomized controlled trial. Setting: Department of Obstetrics & Gynecology, Bahawal Victoria Hospital, Bahawalpur. Period: Two years. July 2014 to June 2016. Sample Technique: Non-probability, consecutive sampling technique. Patients & Methods: A total of 256 patients, 16 to 38 years of age with fetal death or missed abortion on ultrasonography in 2nd trimester (14-24 gestational weeks) of pregnancy were included in the study. Patients with previous uterine surgery, multiple pregnancies and parity>3 were excluded. Then selected patients were placed randomly into two groups i.e. Group A (extra-amniotic Foley?s catheter balloon alone) & Group B (Foley?s catheter balloon along with extra-amniotic instillation of prostaglandin F2-alpha), by using lottery method. Outcome variables like efficacy i.e. expulsion of fetus within 24 hours of induction, were noted. Results: The mean age of women in group A was 24.51 ± 4.77 and in group B was 24.29 ± 4.48 years. The mean gestational age in group A was 21.65 ± 2.01 weeks and in group B was 21.28 ± 1.93 weeks. Efficacy was 103 (80.47%) in group A (extra-amniotic Foley?s catheter balloon alone) and 119 (92.97%) in group B (combined use of Foley?s catheter balloon and extra-amniotic instillation of prostaglandin F2-alpha) with p-value of 0.003. Conclusion: This study concluded that combined use of Foley?s catheter balloon and extra-amniotic instillation of prostaglandin F2-alpha is better and more efficacious than extra-amniotic Foley?s catheter balloon alone in therapeutic termination of second trimester pregnancy.

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