Muhammad Kashif Salman, Muhammad Sohail Ashraf, Ejaz Ahmad.
Comparison of 3.0% hypertonic saline versus 0.9% normal saline nebulization for acute bronchiolitis in children.
J Postgrad Med Inst Jan ;32(02):128-31.

Objective: To compare the use of 3.0% hypertonic saline versus 0.9% normal saline for nebulization in children who presented with acute bronchiolitis. Methodology: We included 76 children having age less than 2 years who presented with acute bronchiolitis in Emergency Department of Nishtar Hospital, Multan, from September 2016 to April 2107. In group I patients, 0.9% normal saline was used for nebulization; and in group II patients 3.0% hypertonic saline was used for nebulization. Nebulization was repeated after every 6 hours. Reduction in modified respiratory assessment (MRA) score after 48 hours and hospital stay were primary outcomes of study. Results: In our study, most of children were in age group of <6 months. The MRA score after 48 hours of nebulization was 4.89 ±1.22 in normal saline group versus 3.34 ±1.05 in patients of hypertonic saline group (p value <0.001). Reduction in MRA score was more in hypertonic saline group as compared to normal saline group. Mean hospital stay was 4.47 ±1.03 days in normal saline group and 3.47 ±0.89 in hypertonic saline group (P value <0.001). Conclusion: Hypertonic saline resulted in significant reductions in modified respiratory assessment score (MRAS) and hospital stay as compared to normal saline in children with acute bronchiolitis.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com