Muhammad Arsalan Aslam, Waseem Ahmad, Tanveer Ahmad Bhatti, Ayesha Tariq.
Correlation OF Hepatitis C Virus Infection With Angiographic Severity Of Coronary Artery Disease.
J Cardiovascular Dis Jan ;14(2):51-7.
INTRODUCTION:It is observed that Hepatitis C virus (HCV) infection is associated with high risk of coronary artery disease (CAD), possibly due to increased inflammation.The determination of the large angiographic burden of CAD in HCV infected cases may provide valuable prognostic information. OBJECTIVES: To find frequency of HCV infection in patients of CAD undergoing coronary angiography and to compare the angiographic burden of CAD in HCV positive and HCV negative patients. MATERIAL & METHODS: This cross-sectional study was done at Department of Cardiology, Mayo hospital, Lahore from 5th July 2016 to 4th Jan 2017. One hundred and fifty patients planned for coronary angiography were tested for anti-HCV antibodies. All the participants were assessed for presence of conventional risk factors. Angiographic burden of CAD was assessed by using modified Reardon severity scoring system and was compared in patients with and without HCV infection. RESULTS: In this study, the prevalence of HCV was 27(18%) among 150 patients of CAD undergoing coronary angiography. The mean age of all cases was 52.88±10.44 years whereas mean age in HCV positive and negative cases was 51.59±12.37 years and 53.16±10.00 years respectively. There were 121(80.67%) male and 29(19.33%) female cases in this study. The male to female ratio was 4.17:1. The conventional risk factors like diabetes mellitus, hypertension, family history and dyslipidemia were found to be more common in HCV positive group. The modified Reardon severity score in HCV positive and negative cases was 9.30 ± 2.74 and 7.84±2.66 respectively (p-value < 0.02). CONCLUSION:The HCV infection in CAD patients undergoing coronary angiography is high i.e. 18% . Coronary risk factors were more frequently seen in HCV positive patients and consequently the angiographic burden of CAD was also high in this group.
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