Ameet Jesrani, Mubarak Ali, Roomi Mahmud, Mustansir H Z, Mahira Yunus, Shabbir Naeem.
Diagnostic Accuracy of Color Doppler Sonography in Evaluation of Renal Transplant Rejection.
Pak J Radiol Jan ;27(1):24-9.

Background: Despite the introduction of new immunosuppressive agents, the incidence of allograft rejection after renal transplantation is still high. Color Doppler Sonography (CDS) is the imaging technique which is safe for the evaluation of a renal allograft. It provides rapid recovery room examination. If warranted, the patient can immediately return to surgery, be referred for testing, or undergo other interventional procedures. Objective: It is aim of present study to determine diagnostic accuracy of Color Doppler Sonography in acute renal transplant rejection with support of histopathological findings as gold standard. Methods: Total 88 patients of either gender with age 20 years or more and suspected of renal transplant rejection within one week to one month after transplantation were included in this study. Color Doppler Sonography was performed and abdominal, serial longitudinal and transverse images were assessed. Resistive index >0.8 was considered graft rejection. Sensitivity, specificity, PPV, NPP, and diagnostic accuracy were calculated taking histopathology as gold standard. The data were analyzed using SPSS and p values of >0.05 were considered as significant. Results: Male patients were 51.1% and female were 48.9%. Mean age was 36.5±10 years. Acute renal transplant rejection was diagnosed in 46.5% patients using Color Doppler Sonography and on histopathology it was observed in 55.6% patients. The sensitivity CDS was 79.2%, while we observed 95% specificity and diagnostic accuracy was found 86.3%. Conclusion: We propose that Color Doppler Sonography (CDS) is an accurate test for diagnosis of acute renal transplant rejection. It is non-invasive and helps to avoid unnecessary surgeries in such patients.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com