Mudassira, Kiran Tauseef, Humaira Zaffar, Anum Usman, Awais Niaz.
Morphological Spectrum of Endometrial Lesions.
Int J Pathol Jan ;15(4):145-8.

Introduction: Abnormal uterine bleeding is one of the commonest presentations in the gynecological clinic in patients of all ages. Most of the cases are managed medically; endometrial biopsy is an important investigation to diagnose the underlying cause after excluding the organic causes of abnormal uterine bleeding. Objective: To determine the frequencies of various endometrial pathologies that are the cause of abnormal uterine bleeding. Methodology: A total of 485 cases of abnormal uterine bleeding were included in this cross-sectional study. Patients with pregnancy related bleeding were excluded. The diagnosis was made on H&E sections and frequencies were calculated by SPSS version 20. Results: Most of the patients with abnormal uterine bleeding undergoing endometrial biopsy were in the age range of 30-40 followed by 40-50 years age. The pathologies related to progesterone excess including estrogen dominance, anovulatory cycles and disordered proliferative endometrium were the most common (39%) underlying cause of abnormal uterine bleeding. 41% of patients had normal proliferative or secretory endometrium. Inadequate samples were only 1%. Conclusion: Endometrial biopsy is important diagnostic investigation to determine treatable causes of endometrial pathologies.

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