Tahmina Gul, Aafrinish Amanat, Rabia Naseer Khan, Khalid Mehmood.
Diagnostic Cytological Yield with and without Ultrasound Guided Fine Needle Aspiration Cytology in Salivary Gland Lesions.
Int J Pathol Jan ;15(4):139-44.

Background: Fine Needle Aspiration Cytology is most commonly used primary diagnostic procedure in the salivary gland lesions. It is minimally invasive, well tolerated, rapid, and inexpensive with a high diagnostic accuracy. Fine needle aspiration cytology is sometimes done with the assistance of ultrasonography. Ultrasound guided fine needle aspiration cytology is comparatively more time consuming and costly procedure. Objective: Compare and correlate the diagnostic cytological yield of conventional method of fine needle aspiration cytology with ultrasound guided fine needle aspiration cytology in salivary gland swellings in order to determine if ultrasonography has substantial advantage to justify additional cost and time. Materials & Method: Random selection was used. Half of the randomized patients underwent Fine Needle Aspiration Cytology without help of ultrasonography and the other half underwent ultrasound guided Fine Needle Aspiration Cytology. A cell block was also processed for histology. Histopathological correlation with the surgical specimen was done in cases where surgical excision was carried out. All the stained cytological and histological slides were analyzed and compared. Data was computerized with window Statistical Package of Social Sciences version 22. Results: The mean age of the study population was 40.44±16.08 years. The male to female ratio was 1.16:1. The sample size was 65. The parotid gland was involved in 38 (58.6%) patients, submandibular gland in 21 (32.3%) patients, submental gland in 2 (3.1%) patients and minor salivary gland was involved in 4 (6.2%) patients. The sensitivity of ultrasound guided fine needle aspiration cytology was 100% with specificity of 82.8%, Positive Predictive Value of 75%, Negative Predictive Value of 100% and diagnostic accuracy was 84.8% taking histopathology as gold standard. The sensitivity of conventional fine needle aspiration cytology was 80% with specificity of 96.3%, Positive Predictive Value of 100%, Negative Predictive Value of 96.3% and diagnostic accuracy was 93.75% taking histopathology as gold standard. Conclusion: Fine needle aspiration cytology without additional ultrasound guidance should be used routinely for the diagnosis of salivary gland lesions as it will save the time and decrease the cost of the test with a high diagnostic accuracy.

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