Shazia Sultana, Shahina Ishtiaq, Urooj Malik, Aqsa Zoey Akhai, Khasheaa Nadeem.
Maternal and perinatal outcome in preterm pre-labor rupture of membranes.
Pak J Surg Jan ;35(1):77-81.

Objectives: To assess frequency of preterm premature rupture of membranes and evaluate maternal & perinatal outcome in pregnancies complicated by preterm premature rupture of membranes (PPROM) in our hospital. Setting: Department of Obstetrics and gynecology Ziauddin hospital which is affiliated with Ziauddin University Period: Three year from 24-January-2013 to 18-December-2016 Study design: This was a prospective cross sectional study. Material and Methods: A total of 62 consecutive singleton pregnancies presenting in labor ward having gestational age between 28 to 36 weeks with complains of leaking per vaginum were included in the study aft er taking informed verbal consent. Frequency of pprom in our hospital, Feto maternal outcome and leaking to delivery interval were noted. The data were analyzed using SPSS version 22.0 statistical package. Results: The frequency of Pprom was 3.27%. The latency period was < 48 hours in 43.5% of patients who presented between 34-36 weeks gestation, while none of those who presented at or < 30 weeks delivered in the first 48 hrs. 35.5% babies were low birth weight (less than 2.5 kg). In 30.6% 5 minute Apgar score of <7 was observed; 34% developed RDS and Perinatal mortality was seen in 26% of babies. Chorioamnionitis complicated 6.45% of pregnancies Conclusion: Pprom is associated with significant increase in perinatal mortality. Duration of PROM, latency period and Apgar score at 5 minute is related with unfavorable fetal outcome. Increase in latency period is also associated with increased risk of chorioamnionitis. Using the findings of this study obstetricians and neonatologists would be in a better position to provide advice to PPROM experiencing couples. Further studies related to long term neonatal morbidity need to have sample sizes that are much larger and should cover a larger number of institutions.

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