Amara Gul, Javed Yousaf.
Effect of levo-dopa on personality disturrbances and dysexecutive symptoms in patients with idiopathic parkinson's disease.
Pak Armed Forces Med J Jan ;68(6):1775-79.

Objective: To assess effects of levodopa (L-dopa) on personality disturbances and dysexecutive symptoms in patients with idiopathic Parkinson’s disease (PD). Study Design: Prospective test-retest design. Place and Duration of Study: Bahawal Victoria Hospital and Civil Hospital, Bahawalpur, Pakistan during June 2016 to June 2017. Material and Methods: Informants of sixty patients with idiopathic PD rated changes in personality on lowa scale of personality change and dysexecutive symptoms on dysexecutive questionnaire after three months of L-dopa treatment. Informants and clinical psychologist who collected data from informants were both blind to the objective of the study. Results: Personality disturbances and dysexecutive functioning (dysexecutive symptoms, inhibition, social regulation) were significantly reduced post L-dopa treatment. Conclusion: L-dopa is an effective treatment for bringing positive personality and cognition related changes in patients with idiopathic PD.

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