Muhammad Ishtiaq Ahmad, Imran Masoud Qasmi, Nazia Dildar, Syed Farrukh Nadeem, Koukab Nadeem.
Validity of a New Ultrasound (USG) Classification System for Differentiating Between Benign and Malignant Solid Thyroid Nodules.
Pak J Radiol Jan ;24(2):51-5.

OBJECTIVE: Evaluate the validity of a new ultrasound classification system in differentiating malignant from benign solid thyroid nodules, keeping FNAB (H/P) as gold standard 2 .  Materilal and Methods : This was a cross sectional validation study conducted in the Department of Radiology, Military Hospital Rawalpindi. Histopathology (FNAB) was carried out at Armed Forces institute of Pathology (AFIP), Rawalpindi by histopathologist. The duration of study was 08 months (November 2012 till June 2013) RESULTS: A total of 210 patients were included in this study. Majority of the patients i.e. 27.14% (n=57) were between      41-50 years, mean and sd was calculated as 42.34 + 4.78 years, 56.19%(n=118) were male and 43.81% (n=92) females, frequency of thyroid nodules (on FNAB as gold standard) reveals as 19.52%(n=41) malignant and 80.48% (n=169) benign, validity of a new ultrasound classification system in differentiating malignant from benign solid thyroid nodules, keeping FNAB (H/P) as gold standard was calculated in Table  No. 4, where 17.62% (n=37) true positive, 4.29% (n=9) false positive, 1.90% (n=4) false negative, 76.19% (n=160) true negative, while sensitivity, specificity, positive predictive value, negative predictive value and validity/diagnostic accuracy was recorded as 90.24%, 94.67%, 80.43%, 97.56% and 93.81% respectively. CONCLUSION: We concluded that the validity of a new ultrasound classification system in differentiating malignant from benign solid thyroid nodules, keeping FNAB (H/P) as gold standard is significantly higher and recommended for diagnosis of malignant solid thyroid nodules in future. KEYWORDS:                                                       Thyroid nodules, new ultrasound classification system, malignant, diagnostic accuracy

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