Shazia Asim, Munazza Ahmad, Salman Iftikhar, Kanza Ahmad.
The Effect of Aloe Vera Extract and Ciprofloxacin on the pH of Urinein Proteus Mirabilis Induced Urinary Tract Infection in Albino Rats.
Pak J Med Health Sci Jan ;8(3):760-5.

Proteus mirabilis is one of the common Gram-negative pathogens that infect the upper urinary tract.Once attached to urinary tract, it infects the kidney and is difficult to eradicate. The frequency of kidney infection by Proteus mirabilisis more than Escherichia coli. Proteus mirabilis may cause severe renal damage such as Acute Pyelonephritis, fever, bacteremia and renal stones. Urease enzyme present in Proteus mirabilis catalyzes the formation of struvite and apatite stones in the kidney and urinary bladder and increases the urinary pH. A rise in urinary pH is indicative of a positive Urinary Tract Infection due to Proteus mirabilis.Aloe vera has a long history of medicinal usage. This study was conducted to observe the effect of Aloe vera extract and its comparison with Ciprofloxacin against Proteus mirabilis induced increase in pH as marker to evaluate its antimicrobial activity against the organism. 50 female albino rats, divided into 5 groups, 10 in each were used. They were artificially induced UTI with Proteus mirabilis. The first group was not treated while the second group was given Ciprofloxacin. The rest of the groups were given Aloe vera whole leaf aqueous extract in three different doses. Urine pH was determined on Day 0, 1, 5, 10 and 15, before and after the administration of Aloe vera extract (in three doses) and Ciprofloxacin. At low doses, Aloe vera had no significant effect on the pH of urine, but a decline in pH was observed in the groups treated with intermediate and high doses of Aloe vera and Ciprofloxacin respectively, over the study period with p-value 0.510 and 0.709 respectively. Conclusion: The reduction in urinary pH with Aloe vera extract is comparable to ciprofloxacin indicating its activity against Proteus mirabilis. It is a potential therapeutic remedy in patients where Ciprofloxacin cannot be used, but it takes longer time to exert its effect.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com