Mudassar Hussain, Abdul Sattar, Anum Jamil, Zafar Ali Chaudhary, Mirza Muhammad Ahsan Baig, Osama Anwaar.
Bacteriological Profile and Antibiogram of Neonatal Sepsis at a Tertiary Care Hospital.
Pak Paed J Jan ;43(2):109-14.

Background: Neonatal sepsis is a common cause of hospitalization of sick neonates. Selection of empirical antibiotic therapy is challenging, primarily due to non-availability of local antibiogram. Objective: To describe the microbial pattern in neonatal sepsis and formulate the respective antibiogram. Study design: Descriptive study. Place and duration of study: Study was conducted at departments of pediatrics and microbiology, Allama Iqbal Memorial Teaching Hospital, Sialkot, from March 2017 to February 2018. Material and Methods: Neonates with clinical diagnosis of sepsis were included in this study. Blood samples were incubated at 370C aerobically for 24 hours. The growth obtained was identified and susceptibility testing of isolated microorganisms was performed. Results: A total of 942 patients were registered in the study. Out of this, 114 (13.7%) samples yielded positive growth and the remaining 828(86.3%) samples were culture negative. Among 114 positive results, 102 (89.5%) showed mono-bacterial growth and 10(8.8%) were identified as Candida species. Two blood culture samples revealed poly-microbial growth (1.7%). Most of the gram negative organisms were sensitive to meropenem, imipenem (93%), piperacillin-tazobactam (67%) and cefoperazone-sulbactam (65%). Conclusion: Our study indicates high level of resistance to commonly used first line antibiotics.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com