Ayesha Azam Khan, Naheed Bashir, Nabeela Shami, Shaila Anwar, Shaheena Asif, Lubna Abid, Raza Akram.
Effect of Raloxifene on T Score of Bones in Post Menopausal Women.
Pak J Med Health Sci Jan ;7(3):688-91.

Aim: To study the effect of 60 mg/ day Raloxifene on bone mineral density in post menopausal women in one year. Study design: A case control study conducted among 30 cases at Defence Hospital and Surgimed Hospital, Lahore from 2011 to 2012. Inclusion Criteria: Age > 50 years, taking 60mg/day Raloxifene >1 year, Menopause > 1 year Exclusion Criteria: Age < 50 years, Bone pathologies, Drug intake, Endocrine pathologies Methods: The patients were divided in two groups; group 1 taking Raloxifene 60 mg/ day for > 1 year, group 2 not taking Raloxifene. All patients were given a questionnaire about age, parity, history of pain & fractures, height shortening, awareness about preventive measures. Then T score of calcaneum bone of both groups measured in OPD by machine. In both the groups value of t score, questionnaire and various bone problems like pain, fracture, height shortening was noted and evaluated statistically, p < 0.05 was significant. Results: There were significantly different results in group 1 and 2. In group 1, t scores were better about above 1.5 (p=0.00), less fractures (n=4) 4% (p=0.003) and no height shortening (n=0) p=0.001 as compared to group 2, whereas pain (n=20) 67% p=0.266 in group 1 and in group 2 (n=22) 76% not significant in both groups. Conclusion: Raloxifene 60 mg/ day significantly increases bone mineral density after 12 months of therapy.

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