Amna Tahir, Muhammad Shoaib, Bilquis Akhtar, Ambreen Khalid, Adeela Shahid, Hamid Javaid Qureshi.
Effect of Type 1 Diabetes Mellitus on Bone Status of Children.
Pak J Med Health Sci Jan ;7(1):251-3.

Background: Children and adolescents with type 1 diabetes mellitus (DM) show severe impairment of bone metabolism and structure, resulting in higher risk of decreased bone mass and its related complications later in life. Objective: To observe the effects of diabetes mellitus on the bone status of children (aged between 9-15 years) by measuring bone remodeling markers and to find out correlation of these parameters with severity of disease itself. Methods: This cross sectional study was carried out in Department of Physiology, University of Health Sciences, Lahore. Sixty boys 9-15 years old were selected. The control group consisted of 30 healthy non-diabetic boys. The diabetic group comprised of 30 boys suffering from type 1 diabetes mellitus. Bone remodeling markers parathyroid hormone (PTH), insulin like growth factor-1 (IGF-1), insulin like growth factor binding protein-3 (IGFBP-3) were determined by ELISA.HbA1C values were determined by affinity liquid chromatography. Bone mineral density ( Z-score) was measured with bone profiler. Results: Difference of level of IGF-1, IGFBP-3 and bone mineral density (Z-score) in both groups were found to be statistically non-significant. However serum parathyroid hormone levels were significantly lower (p<0.05) in diabetic boys as compared to non-diabetic controls. Correlations of parameters with levels of HbA1C and bone mineral density were found to be non-significant. Conclusion: Type 1 diabetes mellitus does not significantly affect bone mineral density and serum levels of IGF-1 and IGFBP-3. However diabetes mellitus results significantly lower levels of parathyroid hormone showing that diabetic children have less bone turn over.

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