Tariq Pervaiz Khan, Fakhar Humayun.
Role of Intravitreal Avastin (Bevacizumab) in Anterior Segment Iris Neo- Vascularization (INV) and Neovascular Glaucoma (NVG) in our population.
Pak J Med Health Sci Jan ;7(1):219-22.

Objective: To assess the efficacy of intravitreal Avastin in regressing iris and anterior chamber angle neovascularization and improving outcome of secondary neovascular glaucoma. Study design: Prospective, consecutive, interventional case series. Materials and methods: The study was conducted in the department of ophthalmology CMH Lahore and CMH Khuzdar for duration of 2 years from May 2010 to May 2012. Fifteen patients (15 eyes) with INV or NVG secondary to ischemic retinal disorders were included in the study. The study group included eleven males (73.33%) and four females (26.66%) aged 27 to 72 years (average, 59 years). Out of 15 cases, 10 had proliferative diabetic retinopathy and remaining five cases were secondary to ischemic central retinal vein occlusion (CRVO).Baseline complete ophthalmic evaluations was carried out included assessment of visual acuity by snellen charts, slit-lamp biomicroscopy of the anterior segment, gonioscopy, applanation tonometry, indirect ophthalmoscopy. Results: Satisfactory regression of Iris (rubeosis) and anterior chamber angle neovascularization was observed in all eyes after one to four injections repeated at monthly intervals. In eight eyes, neovascularization recurred during the follow-up period. The intraocular pressure remained adequately controlled in one eye only. Six eyes were managed with addition of antiglaucoma therapy. Conclusions: Intravitreal bevacizumab seems to be effective in regressing and stabilizing iris neovascularization, and lowering IOP in patients with INV alone and early NVG without angle closure. In advanced cases, Intravitreal bevacizumab cannot control IOP alone but may be used adjunctively to other procedures. However it is likely to extend our therapeutic options in managing neovascular glaucoma in patients with proliferative retinal vasculopathies.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com