Zafar Iqbal, Abdul Sattar, Sajjad Haider, Muhammad Tayyab, Naseer Ahmed Chaudrhy.
Morphological Changes in Aorta and Coronary Arteries of Albino Rats Fed on Palm Kernel Oil and Nigella Sativa.
Pak J Med Health Sci Jan ;7(1):111-3.

Objective: To study the morphological changes in aorta and coronary arteries of albino rats fed on palm kernel oil and Nigella sativa Materials and methods: Sixty albino rats including equal number of males and females were obtained from PCSIR Laboratories, Lahore. At the start of the experiment, they varied from 12-14 weeks of age and of 150-250 grams weight. The rats were divided into four groups labeled as C1, E1, C2 and E2. Each group had 15 rats. Two cc blood was drawn from each rat. A rat ear punch was used for this purpose. All tubes were allowed to stand for 30 minutes at 37°C and tests were measured against reagent blank at 500 nm using Labsystem Chemistry Analyser FP-901. Results: The mean serum total lipid levels±SD showed increase in serum total lipid levels at 0 week and 24 weeks. The difference was statistically very highly significant. Conclusion: Palm kernel oil increased the serum total cholesterol and low density lipoprotein cholesterol, decreased the high density lipoprotein cholesterol levels in all groups at 24 weeks as compared to 0 week samples. Nigella sativa decreased serum total cholesterol and low density lipoprotein cholesterol and increased high density lipoprotein cholesterol levels which were highly significant.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com