Azam Ali, Abdus Sattar, Abdul Hameed, Muhammad Farooq.
Evaluation of Lipid Profile in patients of Primary Hypothyroidism Visiting Cenum.
Pak J Med Health Sci Jan ;7(1):80-2.

Aim: To estimate the lipid profile in patients of primary hypothyroidism. Place of study: Atomic Energy Medical Centre (CENUM), Mayo Hospital Lahore. Methods: Eighty subjects were recruited for this study. 40 subjects were of primary hypothyroidism (B), while the remaining 40 subjects were healthy control group (A). 40 subjects diagnosed as primary hypothyroidism (TSH >10µIu) with age range 18-40 years were selected. 40 age and sex matched euthyroid subjects were selected as controls. The subjects having diabetes mellitus and ischemic heart disease were excluded. The individuals who were on any drug therapy that could alter lipid metabolism and thyroid function were also excluded. 10 ml Antecubital venous blood samples were taken during morning hours (0800-1000), after an overnight fast (12-14 hours) and 30 minutes of supine rest. Serum was obtained for the thyroid profile. Serum samples were analyzed for T3, T4, TSH, TC, TG, LDL-c and HDL-c. Results/Conclusion: Serum TC levels is increased (highly significant) in patients of primary hypothyroidism as compared with control group. Serum TG level is increased (highly significant) in patients of primary hypothyroidism as compared with control group. Serum LDL-c level is increased (highly significant) in patients of primary hypothyroidism as compared with the control group.

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