Asif Maqbool, Imran Mahfooz Khan, Adnan Ahmed Ather.
Efficacy of Intravenous Octreotide in Prevention of Early Variceal Rebleed after Sclerotherapy.
Pak J Med Health Sci Jan ;7(1):73-5.

Objective: To evaluate the efficacy of intravenous octreotide following sclerotherapy in prevention of early variceal re bleed. Methods: 200 patients of variceal bleed were selected for this study. All patients were infused octreotide 50 µg bolus followed by continuous intravenous infusion at 50µg/hour and followed by sclerotherapy 12-24 hours later. After sclerotherapy these 200 cases were continued with intravenous octreotide at 50µg/hour for 48 hours. All patients were observed for evidence of early re bleed within 05 days that is history of hematemesis and melena. Results: In our study the mean age of the patients was 41.3+9.8 years. There were 30(15%) patients of grade 1, 78(39%) patients of grade 2 and 92(46%) patients of grade 3 varices. There were 135(67.5%) patients having ascites and 65(32.5%) patients had ascites absent. In the distribution of re bleed 28(14%) patients had hematemesis and melena present and 172(86%) patients have no presence of hematemesis/melena. Conclusion: Intravenous octreotide is an effective treatment method in prevention of re bleed within 5 days after sclerotherapy in cirrhotic patients.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com