Shafique Ahmed, Shehzad Ahmad, Mohammad Kashif.
Incidence of Heparin-Induced Thrombocytopenia in patients Treated with Unfractionated Versus Low Molecular Weight Heparin after Acute Coronary Syndrome.
Pak J Med Health Sci Jan ;7(1):67-9.

Objective: To compare the incidence of heparin-induced thrombocytopenia with the use of unfractionated versus low molecular weight heparin. Study Design: Case-control type of study. Place and duration of study: Department of Cardiology, Bahawal Victoria Hospital Bahawalpur from 1st October 2011 to 31st March 2012. Methodology: All the patients presenting with the diagnosis of acute coronary syndrome and getting either low molecular heparin (LMWH) or unfractionated heparin (UFH) were enrolled. We recorded the data regarding age, gender, diagnosis, previous history of exposure to UFH, the type of heparin being administered and the timing of onset of thrombocytopenia. Platelet counts of all these patients were monitored after every 24 hours. Clinical scoring for probability of heparin-induced thrombocytopenia was done. The data was analyzed using SPSS software version 10. Results: Overall frequency of heparin induced thrombocytopenia was 2.7 %. There was a significant difference in the frequency of HIT in the two patient groups exposed to LMWH and UFH respectively Conclusion: Risk of heparin-induced thrombocytopenia is less with the use of unfractionated heparin.

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