Romana Maqsood Sheikh, Kiran Butt, Hasan Masood Khan, Arslan M.
Pro-Inflammatory Profile of Extremely Obese Children in a Local Population of Central Punjab, Pakistan.
Pak J Med Health Sci Jan ;7(1):30-5.

Objective: To evaluate the status of pro inflammatory markers in children with extreme obesity. Subjects and methods: 37 children were recruited for the study (20 non obese and 17 obese). Serum concentration of C reactive protein (CRP), α-2 macroglobulin (A2M) and hepatoglobin were measured. Anthropometric findings were correlated with biochemical parameters. Results: Mean serum CRP, A2M and hepatoglobin were several fold higher in obese group as compared to the controls (p value < 0.05). CRP was significantly correlated with body weight (BW), body mass index (BMI) and A2M (p value <0.05). Conclusion: Childhood obesity is associated with a pro-inflammatory state before the appearance of co-morbidities of metabolic syndrome, where as CRP, A2M and hepatoglobin are the most likely indicator of development of inflammation.

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