Moazzam Ali Naqvi, Imran Waheed, Masood Ali Akbar, Tahir Naveed, Adeel Tahir, Zeeshan Hassan.
Hypotension after Streptokinase Therapy in patients Presenting with Acute Myocardial Infarction.
J Cardiovascular Dis Jan ;14(4):87-92.

INTRODUCTION: Streptokinase is the most often used fibrinolytic agent in Pakistan for patients with acute mocardial infarction. However, many side effects including hypotension have been reported. The aim of this study was to determine the frequency of hypotension after intravenous streptokinase in patients presenting with acute ST Elevation myocardial infarction (STEMI). MATERIAL AND METHODS: This was a Descriptive case series study which was done in Emergency Department of Cardiology Ward, Punjab Institute of Cardiology, Lahore from January 2017 to July 2017. Two hundred patients with STEMI were enrolled and were given streptokinase as 1.5 mega-units diluted in l00mls of Normal Saline infused over 60 minutes. After 60 minutes of infusion, patients were assessed for hypotension. RESULTS: The mean age of patients was 52.86+-10.07years. There were 135 (67.5%) males and 65 (32.5%) females. The mean duration of chest pain was 5.64+-3.40hours. In this study,114 (57.0%) patients developed hypotension. CONCLUSION: The frequency of hypotension is high in patients with acute ST Elevation myocardial infarction given streptokinase (SK). So, special attention should be given to patients given SK after AMI to prevent hypotension. KEY WORDS: Hypotension, Acute Myocardial Infarction (AMI), Streptokinase(SK).

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