Dua Zhaira, Asma Nafisa, Nadeem Ikram.
A Mosaic of Risk Factors for Female Infertility in Pakistan.
J Rawal Med Uni Jan ;23(2):80-4.

Background: To identify different risk factors for female infertility including hormonal imbalance (FSH, LH and Prolactin) Methods: Infertile women were enrolled in this prospective study. A questionnaire was designed to collect information regarding socio-demographic and clinical characteristics of the study participants. Serum FSH, LH and Prolactin levels were estimated between 1-5 days of post menstrual period. Independent sample t- test, Spearman correlation and multivariate logistic regression were performed to find the association of different risk factors with female infertility. Results: Highest percentage (57.7%) of infertile females was in the age bracket of 26 to 35 years. The prevalence of primary infertility was 60.4% . Mean levels of LH and prolactin were significantly higher in women with primary infertility compared to those with secondary infertility. No significant difference was observed in the mean level of FSH . A significant positive correlation was found between infertility and age , marital history and infertility duration. On multivariate logistic regression analysis women with secondary infertility were more likely to be hypertensive(OR=2.126,95%CI:1.020-4.474, p-value0.044), using contraceptive OR = 5.876, 95% CI: 2.491–13.86, p-value .001),have hyperprolactenemia (OR=1.289,95%CI:0.960-1.996,p-value0.001) and have marital history of more than 16 years OR=12.166,95%CI:5.048-29.322, p-value0.001). Conclusion:Highest prevalence of infertility was seen in the age group of 26-35 years. Advanced age, hypertension, hyperprolactemia, use of contraceptive and marital history of more than 16 years are significantly associated with female infertility

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