Arfan-ul Haq, Javed Iqbal Bajwa, Khalid Hussain, Asma Munir, Sameen Irfan.
Aspartate Aminotransferase Activity in Gingival Crevicular Fluid during Orthodontic Tooth Movement.
Annals Punjab Med Coll Jun ;11(2):149-53.

Introduction: Movement of teeth during orthodontic treatment takes place as a result of remodeling in periodontium and certain chemical mediators in the form of biomarkers are expressed in gingival crevicular fluid. Objective: To evaluate change of Aspartate Aminotransferase level in gingival crevicular fluid during orthodontic tooth movement. Study design: Randomized control trial; a split mouth design. Setting: Department of Orthodontics, Dental Section, Punjab Medical College Faisal Abad. Duration of study: Six months 01-01-2016 to 30-06-2016. Sample size:  Thirty selected patients. Sampling technique: Non –Probability purposive sampling: Data collection procedure: Full mouth plaque score and full mouth bleeding score were assessed at base line and 28thday. Patients undergoing orthodontic treatment at initial stage of alignment were evaluated where right upper 1st premolars were taken as experimental and left 1st premolar kept as control. A paper point inserted into gingival sulcus for one minute, removed then stored in normal saline. Level of Aspartate Aminotransferase was determined by spectrophotometric automatic apparatus. Data was analyzed using SPSS version 18 and tabulated. Results: Full mouth plaque score slightly increased while full mouth bleeding score showed slight decrease. Aspartate Aminotransferase level in both groups showed insignificant difference at base line and 1hour, however significant difference was found at 1st, 2nd,3rd and 4th week with highest at the end of 1st week. Conclusion: Aspartate Aminotransferase level in gingival crevicular fluid changes with orthodontic tooth movement and may be used as biomarker during orthodontic treatment.

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