Abdul Sattar, Malik Shah Zaman Latif, Muhammad Tayyib.
Estimation of Serum Lipids in Albino Rats fed on Atherogenic Supplemented Palm Oil Diet and Nigella Sativa.
J Rawal Med Coll Jan ;6(2):48-51.

Background: To evaluate the effect of Nigella sativa on the serum lipid profile of albino rats fed on atherogenic supplemented palm oil diet. Methods: Seventy-two albino rats were selected for this study. They were divided into six groups, each comprising of 12 animals. All groups had an equal number of males and females. Fourteen days after acclimatization to the environment and basal diet, fasting blood samples (zero week) were collected by heart puncture under ether anaesthesia. Experimental diets were then started, which continued for 24 weeks. Serum lipids were estimated using enzymatic calorimetric methods. Results: The estimations of serum lipids showed an increase in total cholesterol and HDL cholesterol (HDL-c) levels but a fall in LDL cholesterol (LDL-c) concentrations in groups fed on palm oil diet. Nigella sativa diets significantly decreased serum total cholesterol and LDL-c while HDL-c was raised but non-significantly. Conclusion: Nigella sativa may prevent deposition of lipids in tissues and atherogenesis by decreasing LDL-c in the serum.

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