Amna Mushtaq, Muhammad Nasrullah Khan, Riffat Khursheed, Muhammad Saeed Qureshi, Arif Malik, Sara Zahid, Abdul Manan, Salma Aslam, Mamoona Munir, Mahwish Arooj, Mahmood Hussain Qazi.
Antioxidant Enzyme Activity and Malondialdehyde Concentration in patients with Urticaria Induced By Non Steroidal Anti-Inflammatory Drugs.
Annals Punjab Med Coll Jan ;6(2):110-4.
Objective: The Urticaria caused by NSAIDs was studied for their antioxidant enzyme activity and malondialdehyde (MDA) concentration. Methodology: Patients were divided into two groups; group one act as a control and the remaining group was urticaria patients. The levels of the Thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in the serum were estimated. The enzymatic activity was estimated and compared with different categories of NSAIDs. Results: In present study CAT, SOD and lipid peroxidation product (MDA) were statistically different from that of healthy control and showed significant changes (p< 0.05) while GSH showed a non-significant (p>0.05) value. Conclusion: It is concluded that antioxidative system of the body is accelerated and shows variations in the patient of Urticaria. Moreover, present study shows the co-ordinated enzymatic mechanism and the interrelationship between enzymatic activities in allergy.
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