Sumera Tahir, Nadia Shafique, Saadia Saleem.
Efficacy of Magnesium Sulphate in Prevension of Fits in Severe Pre-Eclampsia.
Annals Punjab Med Coll Jan ;5(2):111-4.

Objective: To evaluate the efficacy of magnesium sulphate as prophylactic agent in prevention of fits in severe pre-eclampsia. Study Design: Interventional Quasi experimental study. Setting: Department of Obstetrics and Gynaecology, Punjab Medical College and affiliated hospitals, Faisalabad. Subject: Sixty patients of severe pre-eclampsia fulfilling the inclusion and exclusion criteria. Main Outcome Measures: Occurrence of fit in case and control group, side effects of the drug like flushing, diminishing of reflexes, respiratory depression and hypotension in the case groupMethod: Sixty patients with severe pre-eclampsia were divided into two groups: Group A was taken as case and treated with MgSO4, group B was taken as control and was not given MgSO4. Results: Out of the 30 patients treated with MgSo4 none (0%) had eclampsia in group A. In group B 4 (13.3%) patients developed eclampsia. Side effects of the drug were looked for in group A. Flushing was seen in 6 (20%) patients diminishing of reflexes was deserved in 1 (3.3%) patient. Conclusion: MgSO4 is an effective drug for prevention of fits in patient of severe pre-eclampsia. 

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