Muhammad Fahad, Rameesha Hussain, Sajjad Hussain, Arooj Fatima, Maryam Paracha.
Comparison of Efficacy of Metered Dose Inhaler and Dry Powder Inhalation in Treatment of Persistent Asthma.
Annals Punjab Med Coll Jan ;12(4):252-5.

Objective: To compare the efficacy of dry powder inhaler versus metered dose inhaler for control of persistent asthma in terms of a mean difference of 500 ml improvement in FEV1 amongst the two groups. Study design: It was Randomized Controlled Trial. Settings: The study was conducted in Medicine Department, Services Hospital, Lahore. Duration: From October 19, 2017 to April 19, 2018. Methodology: A total of 458 patients who fulfilled the inclusion criteria were enrolled in the study. 229 patients in each group were divided using lottery method into two groups (Group-A & Group-B). Metered Dose Inhaler was given to group-A patients for 4 weeks. Dry Powder Inhaler was given to group-B patients for 4 weeks. Follow up by 4th week was done by patient’s outdoor visits by doing pulmonary function tests and measuring forced expiratory volume 1 second. All the collected information was transferred to SPSS v23.0 and analyzed accordingly. Data were stratified for gender, age and duration of disease to address the effect modifiers. For post-stratification, Chi-Square test was used taking p-value ≤0.05 as significant. Results: A total of 458 patients with asthma were examined in this study. Patients were randomly divided in two groups i.e. Group-A (Metered Dose Inhaler) and Group-B (Dry Powder Inhaler). Efficacy was found in 162(70.7%) patients in group-A (Metered Dose Inhaler) while in 126(55.0%) patients in group-B (Dry Powder Inhaler) with a p-value as 0.0004 which was statistically significant. Conclusion: Metered Dose Inhaler (MDI) provides significant improvements in FEV1 versus Dry Powder Inhaler (DPI)

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