Jan Muhammad Afridi, Yasir Rehman, Sabahat Amir, Fazlur Rahim.
Etiological Spectrum and Antibiotic Sensititvity in Children with Acute Pyogenic Meningitis.
J Med Sci Jan ;26(3):234-6.

Objective: To determine the frequency of causative organisms and their sensitivity spectrum in newly diagnosed acute septic meningitis. Material and methods: This study was conducted at department of Pediatrics and Child Health, Khyber Teaching Hospital, Peshawar, Pakistan from June 2017 till December 2017. A cross-sectional descriptive study design was used and 88 patients presenting with clinical signs and symptoms of acute septic meningitis were selected through non randomized convenient sampling. Before enrolling the patients informed consent was taken from the attendant.For every patient a proper record was maintained on a standardized proforma.Detailed history and examination was done with a special emphasis on signs and symptoms suggestive of meningitis were documented. Lumber puncture was performed under aseptic technique and samples were sent for analysis and culture to the Khyber Medical College Pathology Department. Where the CSF culture was performed by Bactec Machine using special culture bottle and the sensitivity pattern was determined against commonly used antibiotics. Patients age less than 15 years with clinical features suggestive of Acute Septic Meningitis were included in the study while those who have taken IV Antibiotics in the last 24-48 hours and Patients with TBM or Viral meningitis were excluded. Results: Out of 88 patients with meningitis 7 (7.9%) patients had positive CSF Culture. 10 patients had staphylococcus Epidermidis growth which was considered contamination. Out of 7 positive culture 3 (3.4%) patients had MRSA positive CSF Culture, 2 (2.2%) patients had Staphylococcus Aurius and 1 (1.1%) patients each had Streptococcus Pneumonie and E.Coli in CSF Culture. Conclusion: In our study it was found that MRSA is the commonest cause of septic meningitis comprising 3 (3.4%) patients followed by Staphylococcus Aurius in 2 (2.2%) and 1 (1.1%) patient each had Streptococcus Pneumonie and E.Coli. Septic meningitis is a serious condition and inappropriate or delay in the management may result in serious fatal complications therefore aggressive and appropriate antibiotic therapy is vital for better outcome.

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