Masood Mazhar, Iqbal Ahmad, Asif Karim.
Frequency of Causative Organism of Urinary Tract Infection in Neonate Presenting with Sepsis.
Pak J Med Health Sci Jan ;12(1):37-41.

Background: Morbidity and mortality both among term and preterm infants is mostly related to neonatal sepsis. Although survival improved and complications reduced in preterm infants due advances in treatment , but sepsis still has major impact on mortality and morbidity in Neonatal care Units. Urinary tract infection (UTI) in neonatal age occurs with neonatal sepsis. Bacteremia may be cause or the effect of UTI. Hypertension and CRF are the complications of Progressive renal damage in early childhood. The clinical manifestations of UTI in the neonatal period may vary and are nonspecific, as well as the sepsis itself. Aim : To determine the frequency of causative organism of Urinary tract infection in neonate presenting with sepsis Setting: This study was carried out in the Department of Pediatric Medicine of B.V. Hospital, Bahawalpur in period of six months. Methods: A total of 251 infants of both gender with UTI and sepsis were included in the study. Preterm newborns and infants with contraindication for bladder catheterization were excluded. We collect under aseptic techniques and obtained from all the patients by bladder catheterization. Samples were properly sent to the laboratory for microscopic analysis and culture /sensitivity , where different medias like Pyocyanin, nutrient agar and TSA (Trypticae soy agar) were used. Data for causative organism was collected and noted. Results: Age range in this study was from 0-28 days. Mean age of infants were 19.004+/- 5.64 days, mean duration of complain was 29.027+/- 7.72 hours and mean weight was 3.117+/-0.37 Kg. Majority of the infants were from 16-28 days (74.9%) of age. Male infants were 78.5%. Pseudomonas was seen in 6.4% patients. E.coli was seen in 39.8% patients. Klebsiella was seen in 36.7% patients. Conclusion: My study concluded that urine culture, analysis, and Gram-stain should be performed in routine work of all patients of neonatal septicemia , especially in males, for early detection and prompt treatment of neonatal UTI.

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