Shazia Azhar, Mamoona Shafiq, Muhammad Usman, Sajjad Ali, Munazza Salahuddin, Sobia Zeeshan.
Gender specific comparison of C-reactive protein and hypercholesterolemia in obese children of Karachi.
Pak J Med Health Sci Jan ;12(1):73-5.

Aim : To determine gender specific comparison of C-reactive protein and hypercholesterolemia in obese children of Karachi . Methods: This descriptive study was carried out in 100 children (5-16 years) by arranging free camp in government higher secondary school in north Karachi in November 2010 to April 2011. Waist-hip ratio and BMI were measured by the criteria given by national heart lung and blood institute. The blood samples were collected to analyze lipid profile and C-reactive protein. Lipid profile was measured by Randox (enzymatic method) ; CRP is estimated by immunochormatographic method. Result: It was observed that body mass index was slightly increased in boys 28.05 +/- 0.33 than girls 27.94 +/-0.34 , whereas waist-hip ratio was significantly increased in girls 1.399 +/- 0.08 when compared with boys 1.89+/- 0.074. Body mass index and waist- hip ratio in children was calculated by Z score). The lipid profile including, cholesterol (280.4+/-3.44) and LDL (175.15+/-3.085) was high in boys as compared with girls , cholesterol (271.54+/-5.72) and LDL (168.86+/-5.88) , whereas HDL (25.27+/-1.35) was increase d in girls as compared with male case (19.75+/-1.035). It was also observed that increased level of triglycerides was observed in both cases boys (177.85+/-4.06) and girls (177.85+/-4.06). Whereas as C-reactive protein was high 14.2+/- 0.45 in boys as compared to girls 13.5+/- 0.47. Conclusion : There is significant rise of inflammatory marker , C-reactive protein, triglycerides and Low- density lipoprotein in obese boys as compared to girls .

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