Muhammad Nauman Shad, Ajaz Fatima, Muhammad Sair, Sadia Chiragh, Zeeshan Ahmad.
Effect of Losartan in Comparison with Pioglitazone on Weights of Liver &Visceral Adipose Tissue on a Rat Model of Type 2 Diabetes Mellitus.
Pak J Med Health Sci Jan ;12(1):254-7.

Background: There is a strong link between type 2 diabetes mellitus (TD2M) and non-alcohol fatty liver disease (NAFLD). The common pathophysiological factor between them is increased insulin resistance. Other features of NAFLD include increased mass of liver and visceral adipose tissue. Objective of this study was to evaluate the beneficial role, if any, of losartan in comparison with pioglitazone onpreventing development of these features of NAFLD. Methods : 45 Sprague-Dawley rats of 5 weeks of age were randomized into three groups. All the rats were fed a high fat and sucrose diet. Pioglitazone and losartan were given along with this diet to the rats in group HFD-PIO and HFD-LOS respectively, while group HFD was kept as control. Body weight and fasting blood glucose levels were determined weekly. At the end of 12 weeks, serum insulin levels were determined. Results: At the end of study periodmean body weight, fasting blood glucose, serum insulin and weight of liver had significantly lower levels in both experimental groups as compared to group HFD. Difference between group HFD-PIO and HFD-LOS was statistically insignificant for all the above parameters. However, mean weight of visceral fat had insignificantly lower levels in both the experimental groups as compared with the control group and difference between the experimental groups was also insignificant . Conclusion : Both losartan and pioglitazone may reduce the progression towards insulin resistance and NAFLD.

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