Hira Kareem, Daniyal Nagi, Romman-ul Haq.
Glomerular Changes in Kidneys of Albino Rats after using Copper diet – a biological study.
Pak J Med Health Sci Jan ;12(1):550-2.

Aim: To evaluate the effects of copper metal on renal glomeruli. Study design: An Experimental study . Duration and place of study: This study was conducted from May to November 2013 in Pathology Department of University of Health Sciences Lahore. Methods : 20 albino rats were selected and divided into two groups. The control group 1 was fed on standard pellet rodent diet and tap water. The experimental group 2 was fed 0.5 mg/kg of body weight for 18 weeks on alternate days; the dose was calculated according to the body weight. Rats were sacrificed at the end of experiment and the kidneys were removed for processing and H&E staining for routine histological study. Glomerular changes observed by microscope and statistically analyzed using Chi-square test with p<0.05.Results : Results showed that glomerular changes in terms of mesangial cell proliferation by using copper in the dietofrats. When the control group 1 on normal diet was compared with the experimental group 2 , statistically significant difference (p<0.05 ) was not iced. Conclusion : It is therefore concluded that copper in diet effect the glomeruli in terms of mesangial cell proliferation ,adhesion and crescent formation in kidneys of albino rats.

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