Iram Inam, Shazia Sehgal.
Effect of Mebendazole Therapy during Pregnancy on birth outcome in patients presenting to Ch. Rehmat Ali Memorial Teaching Hospital.
Pak J Med Health Sci Jan ;12(3):935-7.

Background: Routine antenatal mebendazole therapy in pregnancy can be of great help in reducing the prevalence of anemia. At the moment this drug is not a widely used because of a lack of data on the safety of the drug especially in our population. Aim: To assess the effect of mebendazole therapy during pregnancy on birth outcome. Methods: We observed the effect of mebendazole on the birth outcomes in Ch. Rehmat Ali teaching hospital to the pregnant patients during second and third trimester of pregnancy. We observed the birthweight (low being classified as <2000 g), perinatal mortality, still births, major congenital abnormalities and anemia ( Hb < 10g/dl)among babies of mothers who had taken mebendazole during pregnancy. Results: The rate of the proportion of low-birth weight babies 5.7% and anemia 16.2% was very much less effected while prevalence of congenital abnormalities, still birth and perinatal mortality was none in patients taking mebendazole. Mebendazole therapy during pregnancy is not associated with a significant increase in adverse effects in term of congenital defects, low birth weight, anemia and still births. This therapy could offer beneficial effects to pregnant women in developing countries, where intestinal helminthiases are endemic.

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