Iram Qamar, Saima Mukhtar, Javaria Latif, Wajeeha Israr.
Relationship of Melatonin with Chronic Periodontitis.
Pak J Med Health Sci Jan ;12(3):1011-4.

Aim: To determine a possible link between serum melatonin levels and chronic periodontitis, correlate serum melatonin levels with age and to analyze melatonin levels in diabetic patients with increasing severity of periodontal disease. Methods: In this study 70 subjects were grouped into control (comprising 5 young, 5 old) the diseased group (comprising 30 young, 30 old) suffering from chronic periodontitis with CPI 3 and CPI 4. Among these diseased groups we further studied the melatonin levels of chronic periodontitis in CPI3 and CPI4, diabetic and non-diabetic and the relation of gender with melatonin levels. Serum melatonin levels were assessed using enzyme-linked immunosorbent assay (ELISA). Results: Serum melatonin levels of the control were high as compared to diseased. Levels of melatonin were decreased in old control subjects as compared to young controls. Melatonin was decreased in code 3 compared to code 4. Declined levels of melatonin in females were observed as compared to males. Melatonin was high in old patients compared to young patients suffering from chronic periodontitis. Melatonin was also increased in diabetic patients with chronic periodontitis. Conclusion: The serum melatonin levels vary in different diseased conditions and show the protective role against the infectious diseases as an antioxidant, and free radical scavenger. Therefore, melatonin could be used therapeutically in chronic periodontitis.

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