Muhammad Yasir Arfat.
Comparison of Complications of Intravitreal Bevacizumab with Laser Photocoagulation for the Treatment of Retinopathy of Pre-maturity.
Pak J Med Health Sci Jan ;12(3):1079-81.

Aim: To compare the rate of complications of intra-vitreal bevacizumab (IVB) with laser photocoagulation (LP) for the treatment of retinopathy of pre-maturity (ROP). Methods: This comparative study was conducted on 70 babies with diagnosis of ROP. These babies were recruited from January 2016 to July 2017. In 35 patients, IVB was given for treatment of ROP and in remaining babies LP was used to treat ROP. IVB was given using a 30 Gauge needle under local anesthesia. laser beams at wavelength 810 nm were given for photocoagulation to the entire avascular retina. Relapse rate and high myopia formation was noted till six months after the principal procedure. Relapse rate and occurrence of high myopia was compared between the IVB and LP groups using Chi-square test. Results: There were 80% babies who were having zone I ROP in IVB group and remaining 82.85% babies were having zone I ROP in LP group. Regarding study outcomes, relapse occurred in 2.85% babies in IVB group and in 11.42% babies in LP group (p-value 0.16). High myopia occurred in 5.7% babies in IVB group and in 17.1% babies in LP group ( p-value 0.13). Very high myopia occurred in 2.85% babies and in 37.14% babies in LP group, with significant p-value <0.0001.Conclusion: Intra-vitreal bevacizumab (IVB) is more safe as compared to laser photocoagulation (LP) for treatment of retinopathy of prematurity.

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