Waqas Iqbal Butt, Maira Bhatti, Sabahat Gul.
Morphological and Biochemical Changes in Kidneys of Gentamicin Treated Rats.
Pak J Med Health Sci Jan ;12(3):1266-8.

Aim: To observe morphological and biochemical changes in the kidneys of gentamicin treated rats. Methods : It is an Experimental study conducted in the experimental research laboratory of University of Health sciences, Lahore. 16 albino rats 6-8 weeks old weighing 175-200 grams were divided into two groups having 8 animals each. Group A served as control and was given 1ml distilled water intraperitoneally for 8 days. While group B served as the experimental group and was given 100mg/kg body weight of gentamicin dissolved in 1ml distilled water intraperitoneally for 8 days. At the end of experimental period ; animals were anesthetized. Blood samples were drawn by cardiac puncture for biochemical analysis, and kidneys were removed for histological examination . Results : The histological picture of kidneys showed loss of brush border , pyknosis, karyolysis, and presence of protein casts in lumen of proximal convoluted tubules in treated group. Conclusion : Gentamicin is nephrotoxic with discernable damage to kidney tubules, producing statistically significant rise in serum urea and creatinine.

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