Faiza Mehboob, Saeed Kanwal, Muhammad Kamran Ameer, Naveed Akhter, Nadia Majeed, Shamsa Ijaz.
Effect of Corn Silk Extracton Renal Functions in Acetaminophin Induced Nephrotoxicity in Mice.
Pak J Med Health Sci Jan ;12(4):1423-4.

Aim: To evaluate the effects of corn silk on renal functions in acetaminophin induced nephrotoxicity Study design: Experimental Study . Settings : Anatomy Department. University of Health and Sciences Lahore. From February, 2012 to February, 2013. Methods: Twenty seven male albino mice of age 6-8 weeks and weight 30 +/- 5 gm were used. The control Group A was treated with single injection of 16.6ml/ kg normal saline on day one of the study via intraperitoneal route and was sacrificed on day ten. Group B was treated with single intraperitoneal injection of acetaminophen (600 mg/kg ) and was sacrificed after 2 days. Group C was administered single intraperitoneal injection of acetaminophen (600 mg/kg ) on day one of the experiment followed by theoral gavage of corn silk (CS) extract 400 mg/kg for next 8 days and then sacrificed on day ten. For blood sampling Cardiac puncture was performed. Results: A statistically significant raised (p < 0.005) levels of serum urea and creatinine in group B were observed.In groups C serum urea and creatinine levels were significantly reduced. Conclusion: The results of present study suggest CS extract provides protection against acetaminophen induced nephrotoxicity.

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