Hafsa Kafayat, Mahham Janjua, Iffat Naheed, Tayyaba Iqbal.
To Assess the Prophylactic role of Tranexamic Acid in Reducing Blood Loss during and After 2 Hours of Cesarean Section.
Pak J Med Health Sci Jan ;12(4):1662-5.

Aim: To assess the prophylactic role of tranexamic acid in reducing blood loss during and after two hours of caesarean section. Methods: This randomized controlled trial study was conducted at Lady Aitcheson Hospital, Lahore Unit-4, King Edward Medical University over a period of one year from 1st January 2016 to 31st December 2017. Sixty two participants were enrolled in study. Patients were divided into two groups i.e. group A and group B, randomly using Microsoft excel 5.0 random number generator. The patient groups were matched according to their mean age, parity, gestational age and indication of LSCS. 1gm tranexamic acid (TXA) was given to the subjects included in group A, by slow intravenous injection by the anaesthetist , over 5min at time skin incision. The members of group B were not given TXA. The experienced 3rd year resident of Gynecology and Obstetrics preceded caesarean section. Later, the duty doctor measured the blood loss at two stages. 1st blood loss was measured after the placental delivery till end of LSCS while 2nd at end of LSCS to two hours after baby birth. Results : Women participated in study had mean age of 27.76+/-4.79 yrs with mean gestational age was 39.16+/-1.17 weeks. The mean preoperative Hb in all cases was 11.13+/-0.69 mg/dL. The mean calculated estimated blood loos in group A (Tranexamic acid given) was 711.78+/-20.89 and in group B (Tranexamic acid not given) was 866.92+/-39.23 with significantly lower mean estimated blood loos, p-value <0.001. The mean difference in Hb was 0.46+/-0.10 in the group A and 0.82 +/- 0.13 in the group B with significantly lower change in Hb level, p-value < 0.001.No blood transfusion complication or side effect was noted in group A. Conclusion: Current study elaborates the positive effect of the acid: Tranexamic, resulting in reduced blood loss, but does not reduce Hb in patients giving the birth by CS. No adverse side effect and complication was found. So, in future TA can be utilized in females undergoing caesarean section to reduce burden of blood transfusions.

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