Mahham Janjua, Rabia Wajid, Tehseen Fatima.
Comparison of Efficacy of Nifedipine Alone and with Progesterone Depot for Tocolysis in Preterm Labour.
Pak J Med Health Sci Jan ;12(4):1666-8.

Background: Preterm birth is one of the leading causes of perinatal mortality. The incidence of preterm birth varies across the globe, the rate being between 5-11 %. If threatened preterm labour is recognized and managed in time, perinatal mortality can be reduced. Aim : To compare efficacy of nifedipine alone and with progesterone depot for tocolysis of preterm labour. Methods: This randomized controlled trial was carried out at Department of Obs and Gynae, Lady Willingdon Hospital Lahore from November 2017 to April 2018. A total of 92 patients of preterm labour, fulfilling the inclusion criteria were included in the study. Non-probability, consecutive sampling was done. The selected patients were placed randomly into two groups. In each group, if uterine contractions remained stopped till 48 hours after start of treatment, the treatment was regarded successful; otherwise it was labelled as unsuccessful. Results : The mean age of women in group A was 26.11+/-5.24 and in group B was 25.97+/-5.09 years. The mean gestational age in group A was 33.39+/-2.16 weeks and in group B was 33.67+/-2.33 weeks. Mean parity in group A was 2.34+/-1.51 while in group B was 2.46+/-1.39. There was cessation of uterine contractions till 48 hrs in 22(47.83%) patients in Group A while in Group B, it was seen in 33 (71.74%) pts with p-value of 0.019 Conclusion: Nifedipine along with progesterone depot was associated with higher efficacy for cessation of uterine contractions in preterm labour as compared to oral nifedipine only.

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