Syed Nadeem Mansoor, Tahir Javed, Wajeeha Nadeem, Syed Moiz Nadeem, Fatima Mueez, Syed Maaz Nadeem.
Postoperative Plasma Antithrombin III Concentration in Gynecological Surgery.
Pak J Med Health Sci Jan ;12(4):1687-9.

Aim: Thromboembolic accidents are frequently responsible for morbidity and mortality after major gynecologic surgery. This study was designed primarily to evaluate changes in antithrombin III ( ATIII ) levels during a period extending from a day before surgery to 3rd postoperative day . Place and duration of study : Lady Aitchison hospital, Lahore, Pakistan, from January 1998 to December 1998. Design: It was an observational study. Methodology : Thirty female patients were enlisted in this study project from department of gynecological surgery of Lady Aitchison hospital Lahore. Mean age of these patients was 50.4 years. Two samples of citrate anticoagulated blood were drawn from each patient. First citrated blood sample was taken one day prior to surgery and second sample on third day after surgery. Only one blood sample was drawn from each control. Results: Significant decrease in concentration of antithrombin III was noticed in patient group. This critical fall of about 30% in antithrombin III level may be the result of strong activation of coagulation pathways. This activation of coagulation may result from circulation stasis at surgical site, trauma to local vascular endothelial lining and severe tissue damage from complicated extensive surgery. Conclusion: Our study results confirmed a very highly significant decrease in concentration of AT III on 3rd postoperative day in patients undergoing gynecological surgery.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com