Muhammad Hussnain Iqbal, Asim Rahim, Asma Saeed, Faisal Khan, Kishwar Parveen, Muhammad Asghar Bhatti, Mohammad Mohsin Khan.
Bacterial Infection Frequency and Culture Sensitivity of Bacteria in Cholelithiasis.
Pak J Med Health Sci Jan ;12(4):1860-2.

Background: The potential et iologic factor in Biliary infection is a calculous cholecystitis and pre-emptive antibiotic cover in high risk supposed cases may putoff progress of complications. Bacteria are present in 20-46% of the patients who undergo cholecystectomy for uncomplicated symptomatic gallstone disease. No bacterial segregates have been found in fit persons. Post-operative bug and its avoidance is of concern to most surgeons, since the rate of post-operative wound infection after optional cholecystectomy in unfussy indicative cholelithiasis ranges from 7% to 20%. Culture of bile from the gallbladder at cholecystectomy for patients with unfussy cholelithiasis has exposed mainly E. coli 51% and Klebsiella 26.5% and Pseudomonas aeuroginosa 22.4%. Aim: To ascertain the bacterial growth in bile of patients having symptomatic uncomplicated gallstones and sensitivity for antibiotics namely Ceftiriaxone, Ceftazidime and Gentamycin by culture and sentivity analysis. Study design: Descriptive cross-sectional survey. Setting : Surgical unit II Sir Ganga Ram Hospital, Lahore. Duration of study: Six months from 04-10-15 to 04-4-16. Sample size : 175 cases calculated fulfilling the inclusion criteria were selected for study. These patients underwent cholecystectomy and bile was taken for cult ure sensitivity per operatively. Sampling technique: Non-probability purposive sampling. Results: In this study, bacteria were present in 28% of bile samples of patients suffering from symptomatic uncomplicated gallstones. Ecoli were 51%, Klebsiella 26.5% and Pseudomonas aeuroginosa 22.4%. Sensitivity of Ceftriaxone was 100% for E coli , klebsiella and Pseudomonas aeuroginosa respectively. Conclusion: Bile contains primarily Ecoli, Klebsiella and Pseudomonas aeuroginos in 28% of patients symptomatic uncomplicated cholelithiasis. According to antibiotic sensitivity reports of our study it is concluded that Ceftriaxone is most sensitive antibiotic for patients with infected bile.

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