Afshan Zia, Sidrah Saleem, Muhammad Imran, Muhammad Usman Arshad, Ayesha Ghazal.
In-VitroEfficacy of Imipenem with Tigecycline and Amikacin against Extensively Drug Resistant Acinetobacter Baumannii.
Pak J Med Health Sci Jan ;13(1):60-3.

Aim: To find out effective antibiotic combinations against extensively drug resistant Acinetobacter baumannii due to emerging issues of treatment failures. Design: It was a descriptive study. Place and duration: Department of Microbiology University of Health Sciences Lahore from 1st March 2017 to 31st March 2018. Methodology: Total 50 clinical isolates were collected and identified by standard microbiological procedures including Kirby Bauer disc diffusion for antibiotic susceptibility. Agar dilution method was used to determine the Minimal inhibitory concentration (MIC) for the antibiotics according to Clinical and Laboratory Standards of Institute, CLSI 2017 guidelines. Microdilution checkerboard titration technique was performed to determine the synergistic combinations of antimicrobials by calculating fractional inhibitory concentrations (FICs). Results: In-vitro indifferences among imipenem-tigecycline 49(98%) and imipenem-amikacin 34(68%) combinations was found. Antagonism among combinations of imipenem-tigecycline 1(2%) and imipenem-amikacin 16(32%) was noted. Conclusion: It is concluded from the study that combination of imipenem with tigecycline or amikacin is not a valuable option for treatment against extensively drug resistant Acinetobacter baumannii

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