Mah-e jabeen Sear, Riffat Naeem, Ayesha Fazal, Ira M Qamar, Saima Mukhtar, Shaista Hussain, Hafee Sanaz.
Serum Vitamin-D Levels in Non-Diabetic-Hypertensive and Type 2 Diabetic-Hypertensive patients.
Pak J Med Health Sci Jan ;13(1):64-7.

Background: The Renin Angiotensin System (RAS) is one of the main contributors to insulin resistance which leads to T2DM and its complications. The ACE2/Angiotensin-(1-7)/Mas axis has lately been anticipated to function as a negative regulator of the RAS, consequently, rendering a shielding task against progress of type 2 diabetes, as well as, lowering blood pressure. A disruption in this balance may be implicated in the pathogenesis of hypertension in T2DM patients. Depleted vitamin D levels are allied with both hypertension and diabetes, possibly through its negative control on the RAS. Aim: To measure and compare serum Vitamin D levels in Type 2 Diabetic-Hypertensive and non-Diabetic hypertensive patients. We aimed to highlight the potential use of Vitamin D as a preventive therapy for hypertension and diabetes mellitus. Methods: A particular population of selected subjects was categorized into 2 groups, with 49 subjects in each group. Diabetic and hypertensive patients were selected from the SIMS diabetic Clinic and medical wards, Lahore. Anthrometric parameters, as well as, BSR were recorded in the clinics. Blood samples were collected and stored for evaluating the biochemical parameters in the Physiology Laboratory, UHS. Results: The serum vitamin D levels were higher in group B than those of group A. Conclusion: Although the current study reinforced the fact that both T2DM and hypertension are risk factors for CKD, we were unable to prove that Vitamin D levels are lower in patients with hypertension compounded with diabetes mellitus.

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