Iqbal Alam Khan, Aqeel Ahmad, Abdul Matin Qaisar.
Perioperative Amiodarone Reduces Post-Operative Atrial Fibrillation in CABG patients.
Pak J Med Health Sci Jan ;13(1):326-8.

Aim: To examine the role of amiodarone in terms of reduction in the postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. Study Design: Prospective study Place and Duration: Department of Cardiac Surgery, Sandeman Provincial Hospital Quetta over a period of 1 year from1 st June 2017 to 31st May 2018. Methods: In this study 120 patients of both genders were included. Patient’s ages were ranging from 30 to 80 years. The patients were divided into two groups, 60 patients in amiodarone (Group A) and 60 in control (Group B). Detailed medical history and informed consent was taken from all the patients. Patients with history of atrial fibrillation and chronicobstructive pulmonary disease were excluded from the study. In group A, all the patients received oral amiodarone 400mg the night before surgery , 400mg at 5 AM on the day of surgery and 400 mg PO/NGT BID for four days postoperatively. Group B 60 patients received placebo. Results: In Group A 49(81.67%) patients were males while 11(18.33%) patients were females with mean age 56.7+/-9.6 years. In Group B, 45(75%) patients were males while 15(25%) patients were females with mean age 58.4+/-7.5 years. Postoperative atrial fibrillation occurred in 7(11.67%) patients in group A (amiodarone) while in placebo group 15(25%) patients had atrial fibrillation (p-value 0.015).In group A (amiodarone) atrial fibrillation duration was 11.7+/-5.8 hrs and in control group (Group B) it was 35.8+/-26.6 hrs respectively. The maximum ventricular rate during atrial fibrillation was slower in the amiodarone group than in the control group (103.7+/-20.3 beats per minute and 128.0+/-16.5 beats per minutes respectively. Group A patients had less hospital stay than that of Group B (placebo). There was no difference found in term of mortality between two groups (P value >0.05) Conclusion: Perioperative oral amiodarone administration shows better results in terms of postoperative atrial fibrillation. Amiodarone group had less hospital stay than control group.

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