Zulfiqar Ali Khan, Muhammad Kashif Habib, Nighat Jabeen.
Comparison of Rise in Intraocular Pressure After a Single Intravitreal Injection of Bevacizumab and Triamcinolone Acetonide.
Al-Shifa J Ophthalmol Jan ;14(1):21-7.

Background: There are conflicting reports regarding elevation of intraocular pressure (IOP) after single intravitreal injection of bevacizumab (IVB) and triamcinolone acetonide. Objectives: To compare the rise in IOP after a single intravitreal injection of bevacizumab versus triamcinolone acetonide. Study Design and Settings: Randomized clinical trial conducted at Retina Clinic of Al-Shifa Trust Eye Hospital, Rawalpindi between 21st October 2014 to 21st April 2015. Subjects and Methods: Sixty patients divided into two equal groups by non-probability consecutive sampling After an informed consent, Group 1 was given 1.25mg/0.05ml intravitreal bevacizumab (IVB) injection and Group 2 was given 4mg/0.1ml intravitreal triamcinolone acetonide (IVTA) injection. IOPs were recorded before injection and 30 minutes, 1 day, 1 week and 4 weeks post injection. Results: Mean baseline IOP was 14.57+-1.755 mm of Hg in IVB group and 11.93+-1.112 mm of Hg in IVTA group. Post injection IOPs in IVB group at 30 minutes, 1 day, 1 week and 4 weeks were 17.40+-4.789, 13.20+-2.441, 12.40+-1.923 and 12.87+-2.145 mm of Hg respectively. Post injection IOPs in IVTA group at 30 minutes, 1 day, 1 week and 4 weeks were 21.53+-9.468, 16.60+-4.702, 15.20+-3.380 and 14.57+-3.380mm of Hg respectively. The mean IOP remained significantly higher in IVTA group as compared with IVB group at 30 minutes (p=0.039), 1 day`(p=0.001), 1 week (p=0.001) and 4 weeks (p=0.024). Conclusion: Single 1.25mg/0.05ml Intravitreal bevacizumab injection causes less IOP rise above the baseline as compared to 4mg/0.1ml Intravitreal Triamcinolone Acetonide.

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