Nasir Chaudhry, Muhammad Owais Sharif, Sarmad Zahoor, Muhammad Usman Malik, Usama Iqbal, Alia Anum.
Diagnostic Accuracy of Optical Coherence Tomography in Early Detection of Choroidal Neovascularization in age Related Macular Degeneration.
Al-Shifa J Ophthalmol Jan ;14(4):203-9.

Objectives: To compare the the diagnostic accuracy of optical coherence tomography (OCT) with fundus fluorescein angiography (FFA) in the early detection of choroidal neovascularization in patients with Age Related Macular Degeneration taking FFA as gold standard. Subjects and Methods: A cross sectional study was conducted at one center for 6 months. Two hundred and five patients were enrolled using strict inclusion/exclusion criteria and studied for early detection of CNV in patients with age related macular degeneration. A pair of FFA and OCT images from the same visit was taken from each selected patient and was assessed by same observer. The results of both diagnostic tests were compared determining the diagnostic accuracy of OCT with FFA. Results: A total of 205 cases were included in the study. All cases were between 50-80 years of age, mean was calculated as 65.52, 57.56% (n=118) were male and 42.44% (n=87) were females. Frequency of CNV on FFA was recorded as 38.54% (n=79). Diagnostic accuracy of OCT vs FFA in the early detection of CNV in patients with age related macular degeneration taking FFA as gold standard was calculated which shows sensitivity, specificity, positive predictive value, negative predictive value and accuracy rates as 89%, 73.02%, 67.62%, 92% and 79.51% respectively. Conclusion: Optical coherence tomography (OCT) has higher diagnostic accuracy compared to FFA in the early detection of CNV in patients with Age Related Macular Degeneration.

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